Aluminum may protect the stomach lining from the damaging effects of alcohol and other irritants. Aluminum hydroxide inactivates the gastric digestive enzyme pepsin. However, the principal reason for its inclusion in commercial antacid preparations is to counteract the diarrhea effect of magnesium. Aluminum hydroxide has other uses.
It binds phosphate in the gut lumen to produce insoluble aluminum phosphate, a feature that is useful in kidney failure when the serum phosphate is abnormally high. It is also useful for patients who tend to form phosphate-containing kidney stones. A very small amount of aluminum is absorbed, and brain damage might occur with its long-term use in the treatment of kidney failure. Chronic, excessive use of aluminum hydroxide may deplete the body of phosphate, causing metabolic bone disease e.
Aluminum hydroxide may alter the absorption of certain drugs [including some used to treat cardiac disease or high blood pressure] so they should not be taken simultaneously. It can completely neutralize stomach acid. Nonetheless, it is not always the best choice for regular use. Another disadvantage of calcium carbonate may be the tendency for gastric acid secretion to rebound after calcium is given.
The dose should not exceed 3 g per day. It is a good idea to think of any substance you take for a therapeutic affect as a medication. Tell your doctor about it. This applies whether taking a prescription or over the counter drug, herb, or supplement.
We recommend consultation with a qualified health care professional familiar with your particular circumstances when trying any self-treatment for a chronic or persistent condition. How to Talk to Your Doctor. Peppermint flavoring — Peppermint is the most common antacid flavoring. By relaxing the lower esophageal sphincter to release gas, peppermint encourages the release of a belch after a meal, hence the popularity of after-dinner mints.
Antiflatulent — Simethicone is a surfactant, which presumably by breaking down bubbles within the gut renders gas available for absorption. Despite the lack of evidence of effectiveness, simethicone is included in some popular antacid preparations, thereby increasing their cost. Alginic acid — Prepared from kelp seaweed , alginate acts as a physical acid barrier for the esophagus in gastroesophageal reflux.
It is not an antacid. When ingested, this tasteless and apparently harmless substance floats on gastric fluid to prevent the reflux of acid and pepsin into the esophagus. There are no satisfactory clinical trials, but these preparations have little neutralizing power and are probably of little benefit in those reflux patients who have complicating esophagitis.
Most commercial antacids contain two or more components. The most common combinations are varying concentrations of sodium hydroxide and aluminum hydroxide. Some widely advertised brands, those with additional components and those containing greater concentrations of the effective ingredients, tend to cost more.
There are other antacids that sacrifice efficacy in the interests of taste and acceptability. Space precludes detailed listing of all products. However, labeling is required, and armed with the above information, consumers should be able to select the product most suitable to their needs. Most commercial antacids come with some instructions. It is important to heed the contraindications and not exceed the recommended daily dose.
The need for these antacids is highly individual and regular use should only be as directed by a physician. A common recommendation is to take the antacids after meals and at bedtime. In practice, most users learn to take the antacid when they have symptoms, e. A useful technique is to anticipate the timing of symptoms, such as after spicy foods or at bedtime, and take the antacid before.
Antacids are useful to provide rapid relief of intermittent heartburn, particularly if brought on occasionally by foods or various activities. Cosby acknowledged that his doctor probably knew that he did not want to use the pills for himself. How did he know that, or why do you say he knew that? A Queer History of Quaalude. July 23, Moreover, in many people, there is no inciting agent that can be identified, rather the disorder occurs without any known provocation.
At present, the primary treatment is based upon the neutralization of gastric acid and pepsin with antacids, such as, for example, aluminum hydroxides, calcium carbonates, magnesium hydroxides and sodium bicarbonates. Of less importance, treatment is based upon the inhibition of secretion by histamine H. Unfortunately, both of these treatments have proven to be inadequate. The problem with antacids is that they provide only transient relief.
This disadvantage is emphasized in many people at night where symptomatic relief is not provided. The problem with histamine H. Moreover, the simultaneous administration of antacids and histamine H. See, for example, Steinberg, W. Med J. In brief, the present invention alleviates and overcomes certain of the above-mentioned drawbacks and shortcomings through the discovery of novel pharmaceutical medications and methods for providing immediate, temporary and sustained relief to people who suffer from episodic heartburn.
Generally speaking, the pharmaceutical medications include an effective amount of an antacid and a histamine H. The present invention is based upon the unexpected realization that antacids and histamine H. The novel pharmaceutical medications of the instant invention are formulated so that they can be administered orally on an as needed basis to obtain the symptomatic relief. In other words, it is not necessary to take the novel pharmaceutical medications or practice the methods of the present invention on a regimented schedule to obtain effective relief.
Rather, the medications can be taken and the methods of the present invention can be practiced by people whenever needed, that is, at the onset of pain, discomfort or symptoms, or whenever pain, discomfort or symptoms are experienced. In accordance with the present invention, this is simply accomplished by orally ingesting together or at basically the same time, an effective amount of an antacid and an H.
The above features and advantages of the present invention will be better understood with reference to the following Detailed Description and Examples which are illustrative of the present invention. By way of illustrating and providing a more complete appreciation of the present invention and many of the intendant advantages thereof, the following Detailed Description is given concerning the novel pharmaceutical medications and methods for providing people suffering from episodic heartburn with instant and sustained relief.
As set forth in the Background, by the term "episodic heartburn," it is meant herein to refer to the sensation of burning under the sternum breastbone usually, but not necessarily, associated with the ingestion of different foods.
By the term "histamine H. Exemplary of histamine H. Antacids which may be used in combination with the histamine H. Typical antacids contemplated by the present invention include, for example, aluminum hydroxides, calcium carbonates, magnesium hydroxides, sodium bicarbonates and the like, as well as those antacids that are commercially available.
In accordance with the present inventions, the antacids may be used in dosage amounts conventionally used for treatment of a variety of excess acid-related gastrointestional dysfunctions, as discussed above.
By the terms "immediate, temporary and sustained relief," they too are used in a broad sense herein. It should therefore be appreciated that by the term "immediate and sustained relief," it means herein immediate, temporary and sustained relief which starts within about minutes following ingestion of the active ingredients and continues and remains constant for at least about hours after ingestion of the active ingredients; the actual ingredients being an antacid and a histamine H.
The pharmaceutical medications of the instant invention can be conveniently prepared from, for example, commercially available antacids and histamine H. For example, the pharmaceutical medications may be taken as a single unitary dose containing both the antacid and the histamine H. Likewise, the present invention contemplates taking the ingredients substantially together, but separately in the same or different dosage forms, such as taking the antacid as a liquid dose and the histamine H.
When taking the active ingredients substantially together, but separately in same or different dosage forms, the order in which they are ingested is not critical. In other words, the antacid and the histamine H. It is preferable, however, to formulate the antacids and the histamine H. When commercially available antacids are selected for use in accordance with the present invention, such as Maalox-Plus.
By the term "substantially together," it is meant herein that when the active ingredients, i. For example, the active ingredients may be taken together or within a few seconds to a few minutes of one another. Nevertheless, it is preferable to ingest a single unitary dose which includes both active ingredients and is in liquid form.
Typical dosages include about 30 mls or 2 tablespoons of a high-potency antacid having an acid-neutralizing capacity equal to the present formulations of, for example, Maalox Plus. With respect to the histamine H. For example, a typical dosage amount for providing immediate and sustained relief from episodic heartburn in an adult is about 30 mls of a high potency flavored antacid or the equivalent thereof and about mg to about mg of cimetidine or mg to about mg of ranitidine administered between about one and about four times per day.
Notwithstanding, it should be appreciated that the oral medications of the instant invention are to be taken on an as-needed basis whenever pain or symptoms associated with episodic heartburn is experienced. Antiflatulents may also be used in combination with the antacids and histamine H.
Antiflatulents may be used in the present invention in dosage amounts conventionally used in the treatment of gastrointestinal dysfunction.
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